A new paper resulting from a collaboration between the INSERM PhIND team and STROK@LLIANCE was recently published in the journal Stroke: “Impact of Decompressive Craniectomy on Hemorrhagic Transformation in Malignant Ischemic Stroke in Mice”
This article focuses on the impact of surgical decompressive craniotomy in malignant ischaemic stroke, following endovascular thrombectomy, whether or not this is coupled with pharmacological thrombolysis (Actilyse, rt-PA).
By combining two different surgical techniques (the mouse model of ischemia-reperfusion and decompressive craniotomy) with the two therapeutic approaches used in the treatment of cerebral ischemia in humans (thrombectomy and thrombolysis), the authors have shown that combined with early reperfusion, decompressive craniotomy increases the risk of hemorrhagic transformation.
This preclinical data raises questions, and should lead to clinical investigations aimed at improving patient management.
For more detail: link to the article (open access)
We’d like to take this opportunity to congratulate all the authors on their work.