A very interesting review have been published by our Caen academic partner (PhIND unit, Université de Caen Normandie / INSERM ) concerning the current evidence linking tPA mediated thrombolysis, bradykinin generation and potential subsequent neurovascular damages. While tPA is an important pharmacological tool for acute stroke management, this clot buster also promotes hemorrhagic transformation, symptomatic cerebral edema and angioedema. Preclinical and clinical evidence suggests that intravenous thrombolysis generates large amounts of bradykinin, a peptide with potent pro-inflammatory, and pro-edematous effects. Thus, this tPA-induced generation of bradykinin is a potential target to improve neurological outcome after thrombolysis.

Link to the article